Use of historical controls for animal experiments.

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Use of historical controls for animal experiments.

Statistical methods for the use of historical control data in testing for a trend in proportions in carcinogenicity rodent bioassays are reviewed. Asymptotic properties of the Hoel-Yanagawa exact conditional tests are developed and compared with the Tarone test. It is indicated that the Hoel-Yanagawa test is more powerful than the Tarone test. These tests depend on the beta-binomial parameters ...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1985

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.8563217